Alexis Arquette (born Robert Arquette, July 28, 1969) is an American trans woman, actress, musician, and cabaret performer.
Arquette was born in Los Angeles, California to Brenda "Mardi" Olivia (née Nowak), an actor, poet, theater operator, activist, acting teacher and therapist, and Lewis Arquette, an actor and director. Her paternal grandfather was comedian Cliff Arquette. Her mother was Jewish, the daughter of a Holocaust refugee from Poland, and her father was a convert to Islam and a descendant of explorer Meriwether Lewis. Arquette's siblings are actors Rosanna, Patricia, Richmond and David.
In 1982, at the age of twelve, Arquette's first job was as "this little kid who's on a ride with all these women and whatnot" in the music video "She's a Beauty" by The Tubes. Four years later, Arquette debuted on the big screen with an uncredited bit part as Alexis, the white-faced friend and bandmate of the sexually ambivalent, angst-filled teenager Max Whiteman (Evan Richards) in the comedy film Down and Out in Beverly Hills.
At twenty-two, Arquette landed her first significant acting role, playing a transvestite Georgette in Last Exit to Brooklyn. Sixteen years later, she went through